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《中国科学院院刊(英文版)》2014,(3):248-248
<正>Tuberculosis(TB)is a chronic respiratory disease caused by Mycobacterium tuberculosis and is a serious threat to human health.Every year there are 1.3 million new cases of TB worldwide,100,000 of which are multidrug resistant.The TB burden in China is the second highest in the world.The widespread occurrence of multidrug(MDR)and extensively drug-resistant(XDR)tuberculosis is making the treatment of TB more and more problematic.Research on the mechanisms underlying drug resistance,one of the most important,diffi cult and competitive areas of TB research worldwide,has been carried out in the labs of Professors BI Lijun and ZHANG Xian’en at the Institute of Biophysics,CAS.On September 1st,2013,Nature Genetics 相似文献
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Sonika Gupta Niraj Shende Swati Banerjee Satish Kumar M. V. R. Reddy Bhaskar C. Harinath 《Indian journal of clinical biochemistry : IJCB》2002,17(1):5-8
Tuberculosis remains major health problem in India and developing countries Immunodiagnosis has important role in screening,
diagnosis and management of tuberculosis. SEVA TB ES-31 antigen has shown potential in detecting tuberculous IgG antibody
in earlier studies from our laboratory. In the present study we have analysedSEVA TB ES-31 antigen specific immunoglobulinsIgM, IgA and IgG in clinically and bacteriologically confirmed pulmonary tuberculosis cases to determine the usefulness of specific immunoglobulin
class in the diagnosis of patients attending the hospital.
Of the 30 cases of pulmonary tuberculosis 25 (83.3%) were positive for IgG, 19 (63.3%) for IgM and 16 (53.3%) for IgA. On
combining IgG and IgM positivity, sensitivity was increased to 93.3%. While combining IgG and IgA positivity, sensitivity
increased to 90%. However specificity was decreased to 66.6% and 70% for both of these combinations respectively. It could
be envisaged from this study that IgG antibody detection against ES-31 antigen showed acceptable sensitivity (83.3%) and specificity
(86.6%) compared to IgM or IgA alone or in combination. When immune responses were analysed according to degree of sputum
positivity, IgG response was observed to be predominant in all grades, compared to IgM or IgA antibody. The addition of IgM
or IgA as an adjunct test increases the sensitivity but at the cost of specificity. Hence the detection of IgG alone is more
useful compared to IgM or IgA assay, in detecting tuberculosis disease cases coming to the hospital. 相似文献
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程桂婷 《海南师范大学学报(社会科学版)》2007,20(1):20-24
疾病与文学发生联系古已有之,肺病更是文学作品中的一个常见意象。现代文学30年可以说是肺病意象的狂欢时代。在现代文学的特殊语境中,肺病作为一种特殊意象被赋予了与民族、社会、人性、女权等有关的隐含喻义。论文试图从鲁迅、丁玲、郁达夫三位作家的小说入手,对现代小说中的肺病意象进行一次现象的梳理和诗学的阐释。 相似文献
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刘晓林 《衡阳师范学院学报》2002,23(1):97-100
《红楼梦》对黛玉、香菱的痨症作了较多的描述,两人所患之疾均是以吐血为主症的虚痨,病症为一,而病因实不相同。透过二人疾病发生的原因、治疗、预后等种种异同的现象,就会发现作者对这二个人物的安排是放在相对、相关的位置上来构思的。作者采用了疾病描写的手段,使人物关系更显得云遮雾断,扑朔迷离,从一个侧面充分体现了作品的伟大艺术成就。 相似文献
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Nelleke Bakker 《History of education》2013,42(3):343-361
As elsewhere in the Western world, between 1900 and 1940 the anti‐tuberculosis campaign in the Netherlands produced a wide range of initiatives to promote child health. In each of these the social and the medical were linked, as the hygienic ‘mood’ was encouraged by a child‐saving ethos that focused upon the poor. In this article the author discusses the choices that were made between anti‐tuberculosis interventions for children, the benefits projected on each of these and the categories of children for whom they were meant. Private and voluntary initiatives dominated the field, whereas the state turned out to be very reluctant to take responsibility. Medically controlled health camps for ‘weak’ children were a more important instrument than open‐air schools and mass medical examination. Medical surveillance produced new categories and data which in turn justified the continued growth of child hygiene after tuberculosis had become less of a threat during the 1930s. 相似文献
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J. Pramanik A. N. Lodam C. M. Badole M. V. R. Reddy K. R. Patond B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》2000,15(1):22-28
Trichloroacetic acid (TCA) solubilized and DEAE fractionatedMycobacterium tuberculosis H37Ra excretory-secretory (ES) antigen viz., Mtb EST DE1 and affinity purified goat antibodies to the TCA solubilized ES antigen
(Mtb EST) were explored in detecting tubercular antibody and antigen respectively in sera of bone and joint tuberculosis by
indirect and sandwich ELISA. Out of total 36 bone & joint tuberculosis cases, tubercular antibody was detected by indirect
ELISA in 30 patients (sensitivity 83%), while circulating tubercular antigen was detected by sandwich ELISA in 27 patients
(sensitivity 75%). Out of 34 non tubercular disease control cases, 10 patients showed positive reaction for antibody while
only 4 patients showed positive reaction for antigen. In another group of 34 healthy subjects who were screened, 4 individuals
showed positive reaction for tubercular antibody and 2 cases for antigen. This study shows that antigen detection assay using
affinity purified anti Mtb EST antigen antibody is superior with overall specificity of 91% as compared to antibody detection
assay with 75% specificity in bone & joint tuberculosis. 相似文献
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应对公共卫生安全事件可能产生的严重后果进行分析,并在此基础上根据高校自身状况,针对学生情况制定出紧急处理,并在事后积极与学生沟通交流,避免矛盾,赢得家长的理解和支持。 相似文献
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Jain A 《Indian journal of clinical biochemistry : IJCB》2011,26(3):269-273
Tuberculosis remains a major public health problem globally, with India being one of the high burden countries. The common
causative agent is Mycobacterium tuberculosis but in developing countries M. bovis is reported as a potential human pathogen. Almost 20% of all reported cases of tuberculosis are of extra pulmonary form of
disease. Diagnosis of extra pulmonary tuberculosis (EPTB) is not always possible with conventional methods, due to the long
time required and the paucibacillary nature of samples; hence the need of rapid molecular methods. A prospective study was
conducted on 300 patients of EPTB over a period of 5 years. These patients were suspected cases of tubercular meningitis,
tubercular ascites and tubercular lymphadenitis. Samples analyzed were cerebrospinal fluid, ascitic fluid and lymph node fine
needle aspirate. A two step PCR targeting hup B gene was used. Clinical response to anti tubercular therapy (ATT) was taken as positive (gold standard). PCR for hup B gene was positive in 147 samples out of 155 ATT responders. Of these 85.71% were infected with M. tuberculosis, 9.52% with M. bovis alone and 4.76% showed co infection with both M.tb and M. bovis. The sensitivity and specificity of PCR was 90.32 and 94.48% respectively. 相似文献
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Jaya S. Tyagi 《Resonance》2006,11(9):20-28
Robert Koch was a German physician and scientist who I made wide-ranging contributions to the study of infectious diseases.
He is credited with developing medical microbiology as a new and independent discipline. He is most j renowned for deciphering
the etiology of tuberculosis (TB), anthrax and cholera. He laid down rigorous guidelines for establishing the link between
a pathogen and a particular disease that came to be known as Koch’s postulates. To this day these postulates serve as benchmarks
in the study of infectious diseases. 相似文献